Evaluation of the cytotoxicity and phototoxicity of Caryocar brasiliense supercritical carbon dioxide extract
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چکیده
BACKGROUND Caryocar brasiliense Camb (Pequi) is a typical Brazilian Cerrado fruit tree. Its fruit is used as a vitamin source for culinary purposes and as a source of oil for the manufacture of cosmetics. C. brasiliense supercritical CO2 extracts exhibit antimicrobial activity against the bacteria Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus and also possess antioxidant activity. This study was designed to evaluate the in vitro cytotoxicity and phototoxicity of the supercritical CO2 extract obtained from the leaves of this species. METHODS In vitro cytotoxicity and phototoxicity of C. brasiliense supercritical CO2 extracts were assessed using a tetrazolium-based colorimetric assay (XTT) and Neutral Red methods. RESULTS We found that the C. brasiliense (Pequi) extract obtained by supercritical CO2 extraction did not present cytotoxic and phototoxic hazards. CONCLUSIONS This finding suggests that the extract may be useful for the development of cosmetic and/or pharmaceutical products.
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Author's response to reviews Title:Evaluation of the cytotoxicity and phototoxicity of Caryocar brasiliense supercritical carbon dioxide extract Authors:
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Caryocar brasiliense supercritical CO2 extract possesses antimicrobial and antioxidant properties useful for personal care products
BACKGROUND The cosmetic and pharmaceutical industries have an increasing interest in replacing synthetic antimicrobials in dermatological products due to increased microbial resistance to conventional antimicrobial agents. Pequi (Caryocar brasiliense) is a native fruit tree of the Brazilian Cerrado, specifically used in cosmetics, in the food industry, and for medicinal purposes. Leishmanicidal...
متن کاملCorrection: Caryocar brasiliense supercritical CO2 extract possesses antimicrobial and antioxidant properties useful for personal care products
Author details Department of Clinical Pathology, Faculty of Medical Sciences, University of Campinas (FCM-UNICAMP)-Rua Tessália Vieira de Camargo, 126 Campinas, SP, Brazil. CPQBA-Multidisciplinary Center of Chemical, Biological and Agricultural Researches, University of Campinas (UNICAMP)-Rua Alexandre Cazellato, 999, Vila Betel, Paulínia, SP, Brazil. Rua Horácio Cenci, 345, Apto 32, Campolim, ...
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